Chromatin insulators and cohesins.
نویسندگان
چکیده
منابع مشابه
Roles of Chromatin insulators in gene regulation and diseases
With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...
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a multisubunit protein complex conserved from yeast to humans, plays a major role in sister chromatid cohesion. In Saccharomyces cerevisiae, cohesins bind to chromatin before or during DNA replication and remain bound until the metaphase–anaphase transition. In vertebrate cells, however, most cohesins dissociate from chromatin in early mitosis, long before the onset of anaphase. This is clearly...
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The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood. Here, we mutate SMC1, the gene encoding a cohesin subunit of budding yeast, by random insertion dominant negative mutagenesis to generate alleles that are highly informative for cohes...
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Sister chromatid tethering is maintained by cohesin complexes that minimally contain Smc1, Smc3, Mcd1 and Scc3. During S-phase, chromatin-associated cohesins are modified by the Eco1/Ctf7 family of acetyltransferases. Eco1 proteins function during S phase in the context of replicated sister chromatids to convert chromatin-bound cohesins to a tethering-competent state, but also during G2 and M p...
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Sister chromatid cohesion is mediated by evolutionary conserved chromosomal proteins, termed "cohesins." Using an extension of chromatin immunoprecipitation, we have analyzed the distribution of cohesins Mcd1/ Sccl and Smc1 along yeast chromosome III. Both proteins occur preferentially at the same approximately 23 positions. Sites in a approximately 50 kb region around the centromere give espec...
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ورودعنوان ژورنال:
- EMBO reports
دوره 9 4 شماره
صفحات -
تاریخ انتشار 2008